Definition: A 38-kDa integral membrane glycoprotein of the presynaptic vesicles in neuron and neuroendocrine cells. It is expressed by a variety of normal and neoplastic neuroendocrine cells and is therefore used as an immunocytochemical marker for neuroendocrine differentiation in various tumors. In ALZHEIMER DISEASE and other dementing disorders, there is an important synapse loss due in part to a decrease of synaptophysin in the presynaptic vesicles.
/biosyn /drug eff /physiol /ultrastruct permitted
Other names Synaptophysin, Rat Clone pSR(2) Protein Moiety, Re; Protein P38, Synaptic Vesicle; P38 Membrane Protein, Synaptic Vesicle