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tau Proteins

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Definition: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).     
See Also Tauopathies 		Other names Proteins, tau; Protein, tau; tau Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Mapt protein, mouse  0   *tau Proteins. Mamm Genome 2001 Sep;12(9):700-12
acetyl-valyl-glutaminyl-isoleucyl-valyl-tyrosyl-lysinamide  0   *Oligopeptides tau Proteins. J Biol Chem 2004 Jun 25;279(26):26868-75
Mapt protein, rat  0   *tau Proteins Phosphoproteins.
STH protein, human  0   *tau Proteins. Proc Natl Acad Sci U S A 2002 May 28;99(11):7751-6
Tau-66  0   *tau Proteins. J Neurochem 2001 Jun;77(5):1372-85
tau protein (389-402), synthetic  0   *Genes, Synthetic *Peptide Fragments *Phosphoproteins *tau Proteins. J Biomol Struct Dyn 1994 Dec;12(3):573-9
tau-1 monoclonal antibody  0   *Antibodies, Monoclonal Biological Markers tau Proteins. Exp Neurol 1993 Dec;124(2):315-25
tau protein (182-235)  0   *Peptide Fragments *tau Proteins. FEBS Lett 1992 Oct 26;311(3):235-40
MAPT protein, human  0   *tau Proteins. Science 1987;238(4834):1651

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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