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ISCOMs

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Definition: A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.  coord IM with specific type of vaccine (IM or NIM); DF: ISCOM   
Pharmacological Action Adjuvants, Immunologic
See Also Saponins 		Other names Immunostimulating Complexes; Immuno Stimulating Complexes; Complexes, Immunostimulating; Complexes, Immuno-Stimulating; Immuno-Stimulating Complexes; ISCOM
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PICKCa  0   *ISCOMs. Arch Virol 1993;131(3-4):307-19
feline leukemia virus vaccine  0   *Viral Vaccines *Retroviridae Proteins, Oncogenic Leukemia Virus, Feline ISCOMs.
Pharma Action Adjuvants, Immunologic 		Immunology 1985;135(1):591

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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