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Neurofilament Proteins

More information in Books or onNLM PubMed
Definition: Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)  /biosyn /physiol permitted    Other names Triplet Proteins, Neurofilament; Proteins, Neurofilament Triplet; Proteins, Neurofilament; Protein, Heavy Neurofilament; Neurofilament Protein, Heavy; Neurofilament Triplet Proteins; Heavy Neurofilament Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NF-220 protein, Loligo pealei  0   *Phosphoproteins *Neurofilament Proteins Nerve Tissue Proteins. J Neurochem 2001 Feb;76(4):1022-31
villin headpiece subdomain peptide  0   *Peptide Fragments *Neurofilament Proteins Carrier Proteins. Science 1998 Oct 23;282(5389):740-4
NF70 protein, Helix aspersa  0   *Neurofilament Proteins. J Cell Sci 1995 Nov;108( Pt 11):3581-90
NF-M17 protein, human  0   *Peptide Fragments *Neurofilament Proteins. Biochemistry 1994 Aug 16;33(32):9627-36
NF-M13 protein, human  0   *Peptide Fragments *Neurofilament Proteins. Biochemistry 1994 Aug 16;33(32):9627-36
neurofilament protein NF 68  0   *Neurofilament Proteins Nerve Tissue Proteins. Neuron 1990;5(6):821
neurofilament protein M  111365-29-8   *Neurofilament Proteins. Exp Biol 1989;48(4):187
neurofilament protein H  108688-71-7   *Neurofilament Proteins. Brain Res 1986;387(3):243
neurofilament protein 150  0   *Neurofilament Proteins. J Neurosci Res 1986;16(4):589
neurofilament protein L  0   *Neurofilament Proteins. FEBS Lett 1985;182(2):475

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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