Definition: A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. These are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (From Adams et al., Principles of Neurology, 6th ed, pp984-5)
GEN or unspecified; prefer specifics; coord with specific dysfunction if pertinent; DF: MITOCHONDRIAL ENCEPH
ExamplesMELAS Syndrome; MERRF Syndrome
Other names Encephalomyopathies, Mitochondrial; Mitochondrial Encephalomyopathy; Encephalomyopathy, Mitochondrial
