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Genes, erbB

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Definition: Retrovirus-associated DNA sequences (erbB) originally isolated from, or related to, the avian erythroblastosis virus (AEV). These genes code for the epidermal growth factor receptor (EGFR) family of receptors which is important in the control of normal cell proliferation and in the pathogenesis of human cancer. The genes include erbB-1 (GENES, ERBB-1), erbB-2 (GENES, ERBB-2), and erbB-3, all of which show abnormalities of expression in various human neoplasms.  spell in titles & translations as erbB; GENES, ERBB-1 & GENES, ERBB-2 are also available   
Examples Genes, erbB-1; Genes, erbB-2 		Other names erbB-3 Gene; erbB Gene; erbB 3 Genes; c-erbB-3 Gene; c erbB 3 Genes; Genes, c-erbB-3; erbB-3 Genes; erbB Genes; c-erbB-3 Genes

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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