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Antigens, CD59

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Definition: Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)     
Pharmacological Action Complement Inactivating Agents
Other names Membrane Inhibitor of Reactive Lysis; CD59 Antigen; Protectin; Membrane Attack Complex Inhibition Factor; MACIF; Homologous Restriction Factor 20; HRF20; CD59 Antigens
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CD59b protein, mouse  0   *Antigens, CD59. Am J Hematol 2009 Feb;84(2):65-70
CD59a protein, mouse  0   *Antigens, CD59. Am J Hematol 2009 Feb;84(2):65-70
cationic protein, urate-calcium oxalate stone, human  0   *Ion Channels Antigens, CD59. Scanning Microsc 1993 Sep;7(3):1107-10
CD59 protein, human  101754-01-2   *Antigens, CD59 Complement C8 Erythrocyte Membrane Receptors, Complement. J Exp Med 1987;165(2):572

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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