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Phosphatidylinositol 4,5-Diphosphate

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Definition: A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)      Other names Phosphatidylinositol 4,5 Diphosphate; Phosphatidylinositol 4,5 Biphosphate; 4,5-Diphosphate, Phosphatidylinositol; 4,5-Biphosphate, Phosphatidylinositol; PtdInsP; PtdIns(4,5)P2; PtIns 4,5-P2; Phosphatidylinositol-4,5-Biphosphate; Phosphatidylinositol Phosphate, PtdIns(4,5)P2; Phosphatidylinositol 4,5-Biphosphate; PtdInsP2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
phosphatidylinositol-3,4,5-trisphosphorothioate  0   Phosphatidylinositol 4,5-Diphosphate/*analogs & derivatives. Bioorg Med Chem Lett. 2008 Jan 15;18(2):762-6
dioctanoyl-phosphatidylinositol 4,5-bisphosphate  0   Phosphatidylinositol 4,5-Diphosphate/*analogs & derivatives. J Biol Chem 1998 Jun 5;273(23):14067-70

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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