encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

Staurosporine

More information in Books or onNLM PubMed
Definition: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)     
Pharmacological Action Enzyme Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
10'-(5''-((methoxycarbonyl)amino)-2'-methyl)phenylaminocarbonylstaurosporine  0   Staurosporine/*analogs & derivatives. J Asian Nat Prod Res. 2011 Aug;13(8):765-9
staurprimide  0   Staurosporine/*analogs & derivatives. Cell Stem Cell 2009 May 8;4(5):416-26
7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine  0   Staurosporine/*analogs & derivatives. J Nat Prod 2008 Jun;71(6):1046-8
7-oxo-3,8,9-trihydroxystaurosporine  0   Staurosporine/*analogs & derivatives. J Nat Prod 2008 Jun;71(6):1046-8
AFN941  0   Staurosporine/*analogs & derivatives. Cancer Cell. 2007 Mar;11(3):209-11
selina-4(14),7(11)-diene-8,9-diol  0   Staurosporine/*analogs & derivatives. J Antibiot (Tokyo). 2006 Jun;59(6):331-7
N-carboxamido-staurosporine  0   Staurosporine/*analogs & derivatives. J Antibiot (Tokyo). 2006 Jun;59(6):331-7
ICP-1 compound  0   Staurosporine/*analogs & derivatives. Mol Cancer Ther 2002 Oct;1(12):1067-78
3-hydroxy-4'-N-demethylstaurosporine  0   Staurosporine/*analogs & derivatives. J Nat Prod 2002 Mar;65(3):295-8
3'-demethoxy-3'-hydroxy-4'-N-demethylstaurosporine  0   Staurosporine/*analogs & derivatives. J Nat Prod 2002 Mar;65(3):295-8
3-hydroxy-4'-N-methylstaurosporine  0   Staurosporine/*analogs & derivatives. J Nat Prod 2002 Mar;65(3):295-8
5'-hydroxystaurosporine  0   Staurosporine/*analogs & derivatives. J Antibiot (Tokyo) 2000 Sep;53(9):895-902
4'-N-methyl-5'-hydroxystaurosporine  0   Staurosporine/*analogs & derivatives. J Antibiot (Tokyo) 2000 Sep;53(9):895-902
PKC412  0   Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Anticancer Drug Des 2000 Feb;15(1):17-28
3'-demethoxy-3'-hydroxystaurosporine-O-methyltransferase  EC 2.1.1.-   *Methyltransferases Staurosporine. J Antibiot (Tokyo) 1998 Jul;51(7):679-82
SCH 47112  0   Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Arch Dermatol Res 1997 Aug;289(9):540-6
CGP 44171A  0   Staurosporine/*analogs & derivatives. Eur J Biochem 1995 Nov 15;234(1):317-22
3'-demethoxy-3'-hydroxystaurosporine  0   Staurosporine/*analogs & derivatives. J Antibiot (Tokyo) 1995 Apr;48(4):300-5
4'-demethylamino-4',5'-dihydroxystaurosporine  155416-34-5 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-11,12-dihydroxy-10-methoxy-9-methyl-, (9S-(9alpha,10beta,11alpha,12alpha,13alpha))  Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Mar;47(3):281-8
N-ethoxycarbonyl-7-oxostaurosporine  143086-33-3   Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Cancer Lett 1992 Jun 15;64(2):177-83
7-oxostaurosporine  141196-69-2 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonine-1,3(2H)-dione, 10,11,12,13-tetrahydro-10-methoxy-9-methyl-11-(methylamino)-, (9R-(9alpha,10beta,11beta,13alpha))  Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors Streptomyces. J Antibiot (Tokyo)1992 Feb;45(2):189-94
CGP 42700  121578-39-0 Benzamide, N-(2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-2-(phenylmethyl)-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methyl-, (9alpha,10beta,11beta,13alpha)  Staurosporine/*analogs & derivatives. J Biol Chem 1992 Apr 5;267(10):6905-9
7-O-methyl-UCN 01  125133-74-6   Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. J Pharmacol Exp Ther 1990;255(3):1218
N,N-dimethylstaurosporine  129623-30-9   Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Biochem Pharmacol 1990;40(2):343
4'-demethylamino-4'-hydroxystaurosporine  126572-73-4 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,4)benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-11-hydroxy-10-methoxy-9-methyl-, (9R-(9alpha,10beta,11beta,13alpha))  Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. J Antibiot (Tokyo) 1990;43(2):163
4'-N-benzoylstaurosporine  120685-11-2 Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)  Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		Int J Cancer 1989;43(5):851
7-hydroxystaurosporine  112953-11-4 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)  Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Protein Kinase Inhibitors 		J Antibiot (Tokyo) 1987;40(12):1782

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy