Definition: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
DF: note short X ref
Other names Acid, 12-S-Hydroxyeicosatetraenoic; 12 S Hydroxyeicosatetraenoic Acid; 12-S-Hydroxyeicosatetraenoic Acid; 12-S-HETE; 12-R-HETE; 12-HETE