encyclopedia of medical concepts
ψ 
ψ 

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

More information in Books or onNLM PubMed
Definition: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)  DF: note short X ref    Other names Acid, 12-S-Hydroxyeicosatetraenoic; 12 S Hydroxyeicosatetraenoic Acid; 12-S-Hydroxyeicosatetraenoic Acid; 12-S-HETE; 12-R-HETE; 12-HETE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(20-hydroxyeicosa-5,14-dienoyl)glycine  0   *Lipopeptides 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/agonists. Mech Dev 2008 Sep-Oct;125(9-10):777-85
12,13-dihydroxy-5,8,10,14-eicosatetraenoic acid  121979-37-1   12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/*analogs & derivatives. Lipids 1989;24(4):256
12,20-dihydroxy-5,8,10,14-eicosatetraenoic acid  0   12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/*analogs & derivatives. Proc Natl Acad Sci USA 1984;81(3):903

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy