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Trinucleotide Repeat Expansion

More information in Books or onNLM PubMed
Definition: An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.     
See Also Anticipation, Genetic; Chromosome Fragile Sites; Chromosome Fragility; Fragile X Syndrome; Myotonic Dystrophy 		Other names Trinucleotide Repeats, Expanded; Trinucleotide Repeat, Expanded; Trinucleotide Repeat Expansions; Repeats, Expanded Trinucleotide; Repeat, Expanded Trinucleotide; Repeat Expansions, Trinucleotide; Repeat Expansion, Trinucleotide; Expansions, Trinucleotide Repeat; Expansion, Trinucleotide Repeat; Expanded Trinucleotide Repeats; Expanded Trinucleotide Repeat
 
SubstanceCAS Registry & nameCategoriesSource
GT1 protein, human  0   *Proteins Trinucleotide Repeat Expansion. Am J Med Genet 1999 Dec 15;88(6: 694-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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