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Carbon-Oxygen Ligases

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Definition: Enzymes that catalyze the joining of two molecules by the formation of a carbon-oxygen bond. EC 6.1.  do not confuse with CARBON-OXYGEN LYASES; DF: C O LIGASES   
Examples Amino Acyl-tRNA Synthetases 		Other names Ligases, Carbon-Oxygen; Carbon Oxygen Ligases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
WaaL protein, E coli  EC 6.1.-   *Carbon-Oxygen Ligases *Escherichia coli Proteins Membrane Proteins. Mol Microbiol. 2008 Dec;70(6):1424-40.
WaaL protein, Pseudomonas aeruginosa  EC 6.1.-   *Bacterial Proteins *Carbon-Oxygen Ligases. Mol Microbiol 2007 Sep;65(5):1345-59
DltA protein, Bacillus subtilis  EC 6.1.-   *Bacterial Proteins *Carbon-Oxygen Ligases. FEBS J 2005 Jun;272(12):2993-3003
WaaL protein, Salmonella  EC 6.1.-   *Carbon-Oxygen Ligases. J Biol Chem 2004 Aug 27;279(35):36470-80
REL2 RNA ligase, Trypanosoma brucei  EC 6.1.-   *Carbon-Oxygen Ligases *Mitochondrial Proteins. J Biol Chem 2003 Jul 25;278(30):27570-4
REL1 RNA ligase, Trypanosoma brucei  EC 6.1.-   *Carbon-Oxygen Ligases *Mitochondrial Proteins RNA Editing. J Biol Chem 2003 Jul 25;278(30):27570-4
DREL protein, Trypanosoma brucei  EC 6.1.-   *Carbon-Oxygen Ligases RNA Editing. Mol Cell Biol 2002 Jul;22(13):4652-60
IREL protein, Trypanosoma brucei  EC 6.1.-   *Carbon-Oxygen Ligases RNA Editing. Mol Cell Biol 2002 Jul;22(13):4652-60
prostaglandylinositol cyclic phosphate synthetase  EC 6.1.-   *Carbon-Oxygen Ligases. Acta Diabetol 1996 Jul;33(2):126-38
bacteriochlorophyll a synthase  EC 6.1.-   *Carbon-Oxygen Ligases. J Biol Chem 1997 Apr 11;272(15):9671-6
VanA ligase, Bacteria  EC 6.1.-   *Bacterial Proteins *Carbon-Oxygen Ligases Vancomycin Resistance Drug Resistance, Bacterial. Biochemistry 1991;30(43):10408
macrotetrolide synthase  EC 6.1.-   *Carbon-Oxygen Ligases. Biokhimiia 1989;54(11):1873
chlorophyll synthetase  EC 6.1.-   *Carbon-Oxygen Ligases. Eur J Biochem 1980;109(1):193
polymyxin synthetase L-2,4-diaminobutyrate activating enzyme  EC 6.1.-   *Carbon-Oxygen Ligases. Methods Enzymol 43:579;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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