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2,3-Diphosphoglycerate

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Definition: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)      Other names 2,3-Bisphosphate, Glycerate; 2,3 Diphosphoglyceric Acid; 2,3 Diphosphoglycerate; 2,3 Bisphosphoglycerate; Glycerate 2,3-Bisphosphate; 2,3-Diphosphoglycerate, (D)-Isomer; 2,3-Diphosphoglyceric Acid; 2,3-Bisphosphoglycerate; 2,3-DPG
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
deoxyhaemoglobin-2,3-diphosphoglycerate complex  0   *Hemoglobins *2,3-Diphosphoglycerate. J Mol Biol 1993 Sep 20;233(2):270-4
cyclic-2,3-diphosphoglycerate  88280-54-0 1,3,5,2,4-Trioxadiphosphepane-6-carboxylic acid, 2,4-dihydroxy-, 2,4-dioxide, (R)  *2,3-Diphosphoglycerate. Biochem Biophys Res Commun 1983;116(3):1125

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