encyclopedia of medical concepts
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Transposases

More information in Books or onNLM PubMed
Definition: Enzymes that recombine DNA segments by a process which involves the formation of a synapse between two DNA helices, the cleavage of single strands from each DNA helix and the ligation of a DNA strand from one DNA helix to the other. The resulting DNA structure is called a Holliday junction which can be resolved by DNA REPLICATION or by HOLLIDAY JUNCTION RESOLVASES.     
Examples HIV Integrase 		Other names Transposase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PogZ protein, human  EC 2.7.7.-   *Transposases. J Biol Chem 2009 Apr 24;284(17):11467-77
HARBI1 protein, human  EC 2.7.7.-   *Transposases. Proc Natl Acad Sci U S A 2008 Mar 25;105(12):4715-20
DAYSLEEPER protein, Arabidopsis  EC 2.7.7.-   *Transposases *Arabidopsis Proteins. Nature. 2005 Jul 14;436(7048):282-4
sleeping beauty transposase, human  EC 2.7.7.-   *Transposases. Mol Cell Biol 2004 Oct;24(20):9239-47
Rim2 protein, Oryza sativa  0   *Plant Proteins *Transposases.
TniA transposase  EC 2.7.7.-   *Transposases. J Bacteriol 1994 Jun;176(11):3257-68
Tn5 transposase  0   *Transposases. Nucleic Acids Res 1981 Apr 24;9(8):1873-83
Tn3 transposase  EC 2.7.7.-   *Transposases. J Biol Chem 1981 May 25;256(10):4687-90
Tn10 transposase  0   *Transposases. Cell 1983 Mar;32(3):799-807
Omega Transposase  0   *Transposases. Basic Life Sci 1986;40:5-27
Minos transposase  EC 2.7.7.-   *Transposases. Proc Natl Acad Sci U S A 1995 Oct 10;92(21):9485-9
IS3 transposase  EC 2.7.7.-   *Transposases. J Bacteriol 1990 Feb;172(2):1062-9
IS1 transposase  0   *Transposases. Mol Gen Genet 1987 Mar;206(3):485-90
hobo protein, Drosophila  EC 2.7.7.-   *Transposases *Drosophila Proteins. Cell 1991 Aug 9;66(3):465-71
TAG1 transposase  EC 2.7.7.-   *Transposases Zinc Fingers Arabidopsis Proteins. Plant Cell 2001 Oct;13(10):2319-31
IS1106 Tip protein, Bacteria  0   *Bacterial Proteins *Transposases. Infect Immun 2001 Dec;69(12):7425-36
pogo protein, Drosophila  EC 2.7.7.-   *DNA-Binding Proteins *Transposases *Drosophila Proteins Drosophila melanogaster. Nucleic Acids Res 1999 Jan 15;27(2):455-61
mu transposase  EC 2.7.-   *Transposases. J Mol Biol 1998 Sep 18;282(2):265-74
mariner transposases  0   *DNA-Binding Proteins *Transposases. Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3748-51
IS10 transposase  EC 2.7.7.-   *Transposases. Proc Natl Acad Sci U S A 1995 Aug 29;92(18):8234-8
Pot2 protein, Magnaporthe grisea  0   *Fungal Proteins *Transposases DNA Transposable Elements. Mol Gen Genet 1994 Nov 1;245(3):339-48
Tc1 transposase  EC 2.7.7.-   *DNA-Binding Proteins *Transposases Caenorhabditis elegans Proteins. Biochem Biophys Res Commun 1993 May 14;192(3):1445-52
RAG-1 protein  128559-51-3   *Homeodomain Proteins Genes, RAG-1 Transposases Zebrafish Proteins Ubiquitin-Protein Ligases. Science 1990;248(4962):1517

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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