Definition: Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
coord with precoord organ/neopl term + histol type
Other names Paraneoplastic Cerebellar Syndromes; Paraneoplastic Cerebellar Degeneration, Anti Yo As; Degeneration, Paraneoplastic Cerebellar; Cerebellar Syndromes, Paraneoplastic; Anti Yo Associated Paraneoplastic Cerebellar Degen; Paraneoplastic Cerebellar Syndrome; Cerebellar Syndrome, Paraneoplastic; Anti-Yo-Associated Paraneoplastic Cerebellar Degen; Paraneoplastic Cerebellar Degeneration, Anti-Yo-As; Cerebellar Degeneration, Paraneoplastic
