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RGS Proteins

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Definition: A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.  do not confuse with GTP-BINDING PROTEIN REGULATORS; not the same as RGS tripeptide   
Pharmacological Action GTP Phosphohydrolase Activators 		Other names Regulators of G Protein Signaling Proteins; RGS Protein (G-Protein Signaling); Regulators of G-Protein Signaling Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RGS17 protein, human  0   *RGS Proteins. Brain Res Mol Brain Res 2004 Mar 17;122(1):24-34
RGS8 protein, mouse  0   *RGS Proteins. Kobe J Med Sci. 2008;53(6):275-81
RGS17 protein, mouse  0   *RGS Proteins. Cell Signal 2008 Oct;20(10):1855-64
Rgs17 protein, rat  0   *RGS Proteins. Eur J Neurosci 2007 Nov;26(9):2532-8
methyl N-((4-chlorophenyl)sulfonyl)-4-nitrobenzenesulfinimidoate  0   *Sulfonamides RGS Proteins/antagonists & inhibitors. Biochim Biophys Acta 2007 Sep;1774(9):1213-20
RGS-3 protein, C elegans  0   *RGS Proteins *Caenorhabditis elegans Proteins. Neuron 2007 Jan 4;53(1):39-52
RGS2 protein, rat  0   *RGS Proteins. Cell Signal. 2006 Oct;18(10):1655-63
RGS12 protein, mouse  0   *RGS Proteins. Dev Dyn 2005 Oct;234(2):438-44
R7BP protein, mouse  0   *RGS Proteins Nerve Tissue Proteins. J Biol Chem 2005 Feb 18;280(7):5133-6
RGS7 protein, C elegans  0   *RGS Proteins *Caenorhabditis elegans Proteins. Cell 2004 Oct 15;119(2);209-18
RGS7 protein, human  0   *RGS Proteins Signal Transduction.
Rgs7 protein, mouse  0   *RGS Proteins Signal Transduction.
Rgs12 protein, rat  0   *RGS Proteins.
RGS14 protein, human  0   *RGS Proteins.
Rgs14 protein, mouse  0   *RGS Proteins.
RGS5 protein, human  0   *RGS Proteins Muscle Proteins.
Rgs5 protein, rat  0   *RGS Proteins Muscle Proteins.
Rgs5 protein, Xenopus  0   *RGS Proteins *Xenopus Proteins Muscle Proteins.
Rgs10 protein, mouse  0   *RGS Proteins.
Rgs10 protein, rat  0   *RGS Proteins.
Rgs1 protein, S pombe  0   *RGS Proteins *Schizosaccharomyces pombe Proteins.
Rgs1 protein, rat  0   *RGS Proteins.
Rgs1 protein, mouse  0   *RGS Proteins. J Immunol 2000 May 1;164(9):4720-9
Rgs8 protein, rat  0   *RGS Proteins.
Rgs11 protein, mouse  0   *RGS Proteins Signal Transduction.
Rgs6 protein, mouse  0   *RGS Proteins Signal Transduction.
Rgs6 protein, rat  0   *RGS Proteins Signal Transduction.
RGS1 protein, Arabidopsis  0   *RGS Proteins *Arabidopsis Proteins. Science 2003 Sep 19;301(5640):1728-31
RGS18 protein, human  0   *RGS Proteins. Cell Signal 2002 Jul;14(7):595-606
RGS13 protein, human  0   *RGS Proteins. J Biol Chem 2002 May 10;277(19):16768-74
RGS11 protein, human  0   *RGS Proteins Signal Transduction. J Biol Chem 1999 Oct 22;274(43):31087-93
RGS6 protein, human  0   *RGS Proteins Signal Transduction. J Biol Chem 1999 Oct 22;274(43):31087-93
regulator of g-protein signaling 9  0   *RGS Proteins.
RGS8 protein, human  0   *RGS Proteins.
Rgs7 protein, rat  0   *RGS Proteins Signal Transduction. DNA Cell Biol 1998 Nov;17(11):983-9
RSG7 protein, Drosophila  0   *RGS Proteins *Drosophila Proteins Signal Transduction. DNA Cell Biol 1998 Nov;17(11):983-9
RGS16 protein  0   *RGS Proteins. J Biol Chem 1997 Mar 28;272(13):8679-85; Proc Natl Acad Sci U S A 1997 Jul 22;94(15):7868-72
RGS12 protein, human  0   *RGS Proteins. Biochem Biophys Res Commun 1997 Apr 28;233(3):770-7
Rgs14 protein, rat  0   *RGS Proteins. Biochem Biophys Res Commun 1997 Apr 28;233(3):770-7
EGL-10 protein, C elegans  0   *RGS Proteins *Caenorhabditis elegans Proteins Signal Transduction GTP-Binding Proteins. Cell 1996 Jan 12;84(1):115-25
Rgs5 protein, mouse  0   *RGS Proteins Muscle Proteins. J Biol Chem 1997 Mar 28;272(13):8679-85
Rgs2 protein, mouse  0   *RGS Proteins. J Biol Chem 1997 Mar 28;272(13):8679-85
RGS10 protein, human  0   *RGS Proteins. Nature 1996 Sep 12;383(6596):175-7
RGS4 protein  175335-35-0   *RGS Proteins Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. Nature 1996 Feb 22;379(6567):742-6
regulator of G-protein signalling 19  0   *RGS Proteins. Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11916-20
RGS2 protein, human  0   *RGS Proteins Helix-Loop-Helix Motifs. DNA Cell Biol 1994 Feb;13(2):125-47
RGS1 protein, human  0   *RGS Proteins. J Immunol 1993 May 1;150(9):3895-904

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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