Definition: A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
do not confuse with GTP-BINDING PROTEIN REGULATORS; not the same as RGS tripeptide
Pharmacological ActionGTP Phosphohydrolase Activators
Other names Regulators of G Protein Signaling Proteins; RGS Protein (G-Protein Signaling); Regulators of G-Protein Signaling Proteins