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Carbonic Anhydrase II

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Definition: A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. Deficiencies of carbonic anhydrase II produce a syndrome characterized by OSTEOPETROSIS, renal tubular acidosis (ACIDOSIS, RENAL TUBULAR) and cerebral calcification. EC 4.2.1.-  /antag: coord with CARBONIC ANHYDRASE INHIBITORS    Other names Carbonic Anhydrase Isoenzyme C; Carbonic Anhydrase C
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-N-(4-sulfamoylphenylethyl)-2,4,6-trimethylpyridinium  0   *Pyridinium Compounds *Sulfonamides Carbonic Anhydrase II/antagonists & inhibitors. J Med Chem 2005 Sep 8;48(18):5721-7
4-methyl-5-perfluorophenylcarboximido-delta(2)-1,3,4-thiadiazoline-2-sulfonamide  0   *Sulfonamides *Thiadiazoles Carbonic Anhydrase II/antagonists & inhibitors. J Enzyme Inhib Med Chem 2003 Aug;18(4):303-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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