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Iron Regulatory Protein 1

More information in Books or onNLM PubMed
Definition: A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.      Other names Soluble Aconitase 1; Repressor Protein, Ferritin; IRP 1 Protein; IRE BP1; IRP1 Protein; IRP-1 Protein; IRE-BP1; Ferritin Repressor Protein; Aconitase 1, Soluble; ACO1 Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IRP1 protein, human  EC 4.2.1.3   *Iron Regulatory Protein 1. Science. 2009 Oct 30;326(5953):722-6
IRP1 protein, Manduca sexta  0   *Insect Proteins *Iron Regulatory Protein 1. Insect Biochem Mol Biol 2001 Dec;32(1):85-96

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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