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ADP-ribosyl Cyclase

More information in Books or onNLM PubMed
Definition: A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.     
Examples Antigens, CD38 		Other names Ribose Cyclase, ADP; Hydrolase, cADPR; Hydrolase, Cyclic ADP-ribose; Cyclic ADP ribose Hydrolase; Cyclase, ADPR; Cyclase, ADP-ribosyl; Cyclase, ADP Ribose; Cyclase, 2'-P-ADPR; ADP-ribose Hydrolase, Cyclic; ADP ribosyl Cyclase; 2' Phospho adenosine Diphosphate Ribose Cyclase; 2' P ADPR Cyclase; cADPR Hydrolase; Cyclic ADP-ribose Hydrolase; Adenosine Diphosphate Ribose Cyclase; 2'-Phospho-adenosine Diphosphate Ribose Cyclase; ADPR Cyclase; 2'-P-ADPR Cyclase; ADP Ribose Cyclase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cyclic guanosine diphosphate-ribose  0   *Guanosine Diphosphate Sugars ADP-ribosyl Cyclase. J Biol Chem 1994 Dec 2;269(48):30260-7
ADP-ribosyl cyclase 2  EC 3.2.2.5   *Antigens, CD *ADP-ribosyl Cyclase GPI-Linked Proteins Hematopoiesis. Proc Natl Acad Sci U S A 1994 Jun 7;91(12):5325-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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