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Sirtuins

More information in Books or onNLM PubMed
Definition: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.     
See Also Silent Information Regulator Proteins, Saccharomyc
Examples Sirtuin 1; Sirtuin 2; Sirtuin 3 		Other names Sir2 like Proteins; Silent Mating Type Information Regulator 2 like Pr; Silent Mating Type Information Regulator 2-like Pr; Sir2-like Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
sirtuin 6, rat  EC 3.5.1.-   *Sirtuins. PLoS One 2011;6(2):e17057
SIRT5 protein, mouse  0   *Sirtuins. Cell 2009 May 1;137(3):560-70
Sirt7 protein, mouse  0   *Sirtuins. J Physiol Pharmacol 2008 Dec;59 Suppl 9():201-12
SIRT5 protein, rat  EC 3.5.1.-   *Sirtuins. Biochem Biophys Res Commun 2008 Aug 22;373(2):246-52
SIRT4 protein, human  EC 3.5.1.-   *Mitochondrial Proteins *Sirtuins. J Biol Chem 2007 Nov 16;282(46):33583-92
SIRT6 protein, human  EC 3.5.1.-   *Sirtuins. Int J Oncol. 2006 Feb;28(2):447-56
SIRT4 protein, mouse  EC 3.5.1.-   *Mitochondrial Proteins *Sirtuins. Cell 2006 Sep 8;126(5):837-9
SIRT7 protein, human  0   *Sirtuins. Biochem Biophys Res Commun 2000 Jul 5;273(2):793-8
SIRT5 protein, human  EC 3.5.1.-   *Sirtuins. Cytogenet Genome Res 2006;112(3-4):208-12
SIR-2.1 protein, C elegans  EC 3.5.1.-   *Caenorhabditis elegans Proteins *Sirtuins. Dev Cell 2005 Nov;9(5):605-15
Sirt6 protein, mouse  EC 2.4.2.31   *Sirtuins. J Biol Chem 2005 Jun 3;280(22):21313-20
cobB protein, E Coli  EC 3.5.1.-   *Escherichia coli Proteins *Sirtuins. J Mol Biol. 2004 Mar 26;337(3):731-41
Sir2 protein, Kluyveromyces lactis  EC 3.5.1.-   *Fungal Proteins *Sirtuins.
Sir2 protein, Drosophila  EC 3.5.1.-   *Histone Deacetylases *Drosophila Proteins *Sirtuins.
sirtinol  0   *Benzamides *Naphthols Sirtuins/antagonists & inhibitors. J Biol Chem 2001 Oct 19;276(42):38837-43

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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