Definition: A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
Other names Ribosomal Protein S6 Kinases, 90 kDa; Ribosomal Protein S6 Kinase, 90 kDa; MAPKAP Kinase 1; MAP Kinase Activated Protein Kinase 1; MAP Kinase Activated Kinase 1; pp90(rsk); p90(rsk); p90 Ribosomal S6 Kinase; Ribosomal Protein S6 Kinase, 90-kDa; MAPKAPK1; MAPKAP-K1; MAPKAP Kinase-1; MAP-Kinase-Activated Protein Kinase 1; MAP-Kinase-Activated Kinase 1
