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Eukaryotic Initiation Factor-3

More information in Books or onNLM PubMed
Definition: A multisubunit eukaryotic initiation factor that contains at least 8 distinct polypeptides. It plays a role in recycling of ribosomal subunits to the site of transcription initiation by promoting the dissociation of non-translating ribosomal subunits. It also is involved in promoting the binding of a ternary complex of EUKARYOTIC INITIATION FACTOR-2; GTP; and INITIATOR TRNA to the 40S ribosomal subunit.      Other names EIF3; Peptide Initiation Factor EIF 3; Int 6 Gene Product; Initiation Factor-3, Eukaryotic; Int 6 Protein; Gene Product, Int-6; Eukaryotic Translation Initiation Factor 3, Subuni; Eukaryotic Peptide Initiation Factor 3, alpha Subu; Eukaryotic Peptide Initiation Factor 3, Subunit 4; Eukaryotic Peptide Initiation Factor 3, Subunit 3; Eukaryotic Peptide Initiation Factor 3, Subunit 2; Eukaryotic Peptide Initiation Factor 3, Subunit 1; Eukaryotic Peptide Initiation Factor 3; Eukaryotic Initiation Factor 3, zeta Subunit; Eukaryotic Initiation Factor 3, gamma Subunit; Eukaryotic Initiation Factor 3, delta Subunit; Eukaryotic Initiation Factor 3, beta Subunit; Eukaryotic Initiation Factor 3, Subunit 8; Eukaryotic Initiation Factor 3, Subunit 7; Eukaryotic Initiation Factor 3, Subunit 6
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
EIF3M protein, human  0   *Eukaryotic Initiation Factor-3. Nature. 2009 Jul 2;460(7251):123-7
EIF3L protein, human  0   *Eukaryotic Initiation Factor-3. J Biol Chem 2001 Dec 7;276(49):45988-95
RPG1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Eukaryotic Initiation Factor-3. Curr Genet 1998 Feb;33(2):100-9
EIF3A protein, human  0   *Eukaryotic Initiation Factor-3. DNA Cell Biol 1997 Apr;16(4):515-31
TIF34 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Eukaryotic Initiation Factor-3. Mol Cell Biol 1997 Jan;17(1):145-53
EIF3I protein, human  171601-26-6   *Eukaryotic Initiation Factor-3 Receptors, Transforming Growth Factor beta. Nature 1995 Oct 12;377(6549):548-52
NIP1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Eukaryotic Initiation Factor-3. Proc Natl Acad Sci U S A 1992 Nov 1;89(21):10355-9
Prt1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Eukaryotic Initiation Factor-3. J Biol Chem 1987;262(6):2845

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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