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4-Quinolones

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Definition: QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.     
Examples Nalidixic Acid; Nedocromil; Oxolinic Acid 		Other names 4 Quinolones; 4 Quinolinones; 4 Oxoquinolines; 4-Quinolinones; 4-Oxoquinolines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pyrrolo(3,2-c)quinolin-4-one  0   *4-Quinolones. J Org Chem. 2011 Jul 1;76(13):5346-53
(6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)-4-hydroxy-2-oxo-3-butenoic acid  0   *Butyric Acids *4-Quinolones. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4806-9
2-heptyl-4-quinolone  0   *4-Quinolones. Chem Biol. 2007 Jan;14(1):87-96
1-tert-butyl-7-tert-butylamino-6-nitro-1,4-dihydro-4-quinolone-3-carboxylic acid  0   *4-Quinolones. Bioorg Med Chem Lett 1999 Jun 21;9(12):1651-6
rosoxacin N-oxide  40034-68-2 3-quinolinecarboxylic acid, 1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-, N(7)-oxide  *4-Quinolones. J Chromatogr 1979;173(1):155

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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