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Carboxylesterase

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Definition: Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.      Other names amidase, Isocarboxazid; Non specific Esterase; Non specific Carboxylesterase; Lipase, Carboxylester; Hydrolase, Carboxylic Ester; Esterase, Procaine; Esterase, Nonspecific; Esterase, Non-specific; Esterase, Naproxen; Esterase, Carboxylate; Esterase ES 1A; Ester Hydrolase, Carboxylic; Enzyme, Capsaicin-Hydrolyzing; Enzyme, CAP-hydrolyzing; ES-1A, Esterase; Carboxylesterase, Non-specific; Capsaicin Hydrolyzing Enzyme; CAP hydrolyzing Enzyme; B esterase; Ali esterase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
carboxylesterase 1A2, human  EC 3.1.1.1   *Carboxylesterase. Pharmacogenet Genomics 2007 Jan;17(1):1-10
carboxylesterase 1A1, human  EC 3.1.1.1   *Carboxylesterase. Pharmacogenet Genomics 2007 Jan;17(1):1-10
CES2 protein, human  EC 3.1.1.1   *Carboxylesterase. Drug Metab Dispos 2006 Oct;34(10):1734-41
cauxin protein, Felis catus  EC 3.1.1.1   *Carboxylesterase. Biochem J 2003 Feb 15;370(Pt 1):101-10
hydrolase B, rat  EC 3.1.1.1   *Carboxylesterase. Arch Biochem Biophys 1994 Dec;315(2):495-512
carboxylesterase Est30, Bacillus  EC 3.1.1.1   *Carboxylesterase. Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1472-3
esterase 1F, mouse  EC 3.1.1.1   *Carboxylesterase.
esterase-S, Drosophila  EC 3.1.1.1   *Drosophila Proteins *Carboxylesterase. Nucleic Acids Res 1993 Jul 25;21(15):3545-51
ESA4 protein, human  EC 3.1.1.1   *Carboxylesterase. Proc Natl Acad Sci U S A 1981 Sep;78(9):5734-8
Es30 protein, mouse  EC 3.1.1.1   *Carboxylesterase. Biochem Genet 1993 Aug;31(7-8):279-94
Es29 protein, mouse  EC 3.1.1.1   *Carboxylesterase. Biochem Genet 1992 Aug;30(7-8):421-36
Es12 protein, mouse  EC 3.1.1.1   *Carboxylesterase. Genomics 1989 Oct;5(3):415-22
hydrolase A protein, rat  EC 3.1.1.1   *Carboxylesterase. Arch Biochem Biophys 1994 Dec;315(2):495-512
EST5B protein, Drosophila  EC 3.1.1.1   *Drosophila Proteins *Carboxylesterase. Mol Biol Evol 1990 Nov;7(6):525-46
Es1 protein, mouse  EC 3.1.1.1   *Carboxylesterase.
ES-HVEL protein, rat  EC 3.1.1.1   *Carboxylesterase. Biochem J 1990 Jul 15;269(2):451-8
esterase 6 protein, Drosophila  EC 3.1.1.1   *Drosophila Proteins *Carboxylesterase. Genetica 1993;88(1):11-28
LipB protein, Bacillus subtilis  EC 3.1.1.1   *Bacterial Proteins *Carboxylesterase. Eur J Biochem 2000 Nov;267(21):6459-69
FE4 protein, Myzus persicae  EC 3.1.1.1   *Insect Proteins *Carboxylesterase. Biochem J 1998 Feb 15;330( Pt 1):169-73
ESD protein, human  EC 3.1.1.1   *Carboxylesterase. Ann Hum Biol 5(3):281;1978; Forensic Sci 14(1):1;1979; Human Hered 25:(5):378;1975; J Forensic Sci 23(1):89;1978; Med Sci Law 15(2):102;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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