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1-Alkyl-2-acetylglycerophosphocholine Esterase

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Definition: A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.      Other names Platelet activating Factor Acetylhydrolase IB; Platelet Activating Factor Hydrolase; Phospholipase A2, Lipoprotein-Associated; PAF 2 Acylhydrolase; PAF 2 Acetylhydrolase; Lipoprotein Associated Phospholipase A2; Hydrolase, Platelet-Activating Factor; Factor Hydrolase, Platelet-Activating; Esterase, 1-Alkyl-2-acetylglycerophosphocholine; Acetylhydrolase, PAF; Acetylhydrolase II, PAF; 2-Acetylhydrolase, PAF; 1 Alkyl 2 acetylglycerophosphocholine Esterase; Platelet-activating Factor Acetylhydrolase IB; PAF Acetylhydrolase II; PAF 2-Acylhydrolase; PAF 2-Acetylhydrolase; Lipoprotein-Associated Phospholipase A2; Lipoprotein-Associated Phospholipase A(2); Lp-PLA(2)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PAFAH1B3 protein, human  EC 3.1.1.47   *1-Alkyl-2-acetylglycerophosphocholine Esterase. J Biol Chem. 2011 Oct 7;286(40):34820-9.
Pafah2 protein, mouse  EC 3.1.1.47   *1-Alkyl-2-acetylglycerophosphocholine Esterase. J Biol Chem 2008 Jan 18;283(3):1628-36
PAFAH1B2 protein, human  EC 3.1.1.47   *Microtubule-Associated Proteins *1-Alkyl-2-acetylglycerophosphocholine Esterase Platelet Activating Factor. Thromb Haemost 2007 Sep;98(3):587-92
Lis1b protein, zebrafish  EC 3.1.1.47   *Microtubule-Associated Proteins *Zebrafish Proteins *1-Alkyl-2-acetylglycerophosphocholine Esterase. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14819-24
Lis1a protein, zebrafish  EC 3.1.1.47   *Microtubule-Associated Proteins *Zebrafish Proteins *1-Alkyl-2-acetylglycerophosphocholine Esterase. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14819-24
Pafah1b1 protein, mouse  EC 3.1.1.47   *Microtubule-Associated Proteins *1-Alkyl-2-acetylglycerophosphocholine Esterase.
PAFAH1B1 protein, human  EC 3.1.1.47   *Microtubule-Associated Proteins *1-Alkyl-2-acetylglycerophosphocholine Esterase Platelet Activating Factor. Nat Genet 1993 Sep;5(1):3-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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