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Mineralocorticoid Excess Syndrome, Apparent

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Definition: A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS.      Other names Apparent Mineralocorticoid Excess Syndrome
 
SubstanceCAS Registry & nameCategoriesSource
Apparent mineralocorticoid excess  0   *Mineralocorticoid Excess Syndrome, Apparent.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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