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Aryldialkylphosphatase

More information in Books or onNLM PubMed
Definition: An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).  X refs PARAOXONASE-1 and PARAOXONASE-2 see SCR for organism specific terms    Other names Thiolactone Hydrolase, Homocysteine; Phosphatase, Aryl-dialkyl; Paraoxonase 2; Paraoxonase 1; Hydrolase, Organophosphorus Acid; Hydrolase, Organophosphorus; Hydrolase, Homocysteine Thiolactone; Enzyme, OPH; Aryl dialkyl Phosphatase; Anhydrolase, Organophosphorus Acid; Anhydrase, Organophosphorus Acid; Anhydrase, OPA; Acid Hydrolase, Organophosphorus; Acid Anhydrolase, Organophosphorus; Acid Anhydrase, Organophosphorus; Paraoxonase-2; Paraoxonase-1; Organophosphorus Hydrolase; Paraoxonase; Organophosphorus Acid Hydrolase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PON1 protein, mouse  EC 3.1.8.1   *Aryldialkylphosphatase. Adv Exp Med Biol. 2010;660():89-97
PON3 protein, mouse  EC 3.1.8.1   *Aryldialkylphosphatase. Adv Exp Med Biol. 2010;660():73-87
MEC-6 protein, C elegans  EC 3.1.1.2   *Caenorhabditis elegans Proteins *Aryldialkylphosphatase. Nature 2002 Dec 12;420(6916):669-73
PON2 protein, human  EC 3.1.8.1   *Aryldialkylphosphatase.
PON1 protein, human  EC 3.1.8.1   *Aryldialkylphosphatase.
PON3 protein, human  EC 3.1.8.1   *Aryldialkylphosphatase. Genomics 1996 May 1;33(3):498-507

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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