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Receptor, Serotonin, 5-HT1D

More information in Books or onNLM PubMed
Definition: A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.      Other names Receptors, Serotonin 1D; Receptor, 5-Hydroxytryptamine1D; Receptor, 5-HT1D; 5 Hydroxytryptamine1D Receptor; 5 HT1D Receptor; Serotonin 1Dalpha Receptors; Serotonin 1Dalpha Receptor; Serotonin 1D Receptors; Serotonin 1D Alpha Receptor; Receptor, Serotonin 1Dalpha; Receptor, Serotonin 1D; 5-Hydroxytryptamine1D Receptor; 5-HT1Dalpha Receptor; 5-HT1D Receptor; 5-HT(1Dalpha) Receptor; 5-HT(1D) Receptor; Serotonin 1D Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-(2-(4-(2-methyl-5-quinolinyl)-1-piperazinyl)ethyl)-4H-imidazo(5,1-c)(1,4)benzoxazine-3-carboxamide  0   *Benzoxazines Receptor, Serotonin, 5-HT1A Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D. J Med Chem 2010 Aug 12;53(15):5827-43
PNU 142093  0   *Benzopyrans *Piperazines Receptor, Serotonin, 5-HT1D/agonists. J Pharmacol Toxicol Methods 2009 Jul-Aug;60(1):51-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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