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SKP Cullin F-Box Protein Ligases

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Definition: A subset of ubiquitin protein ligases that are formed by the association of a SKP DOMAIN PROTEIN, a CULLIN DOMAIN PROTEIN and a F-BOX DOMAIN PROTEIN.     
See Also Cullin Proteins; F-Box Proteins; S-Phase Kinase-Associated Proteins
Examples Cullin Proteins 		Other names Ubiquitin Ligases, SKP1-Cullin; Ubiquitin Ligase, Skp1-Cullin-1-F-box; Ubiquitin Ligase, SCF; Skp1 Cullin F Box Proteins; Skp1 Cullin 1 F box Ubiquitin Ligase; SKP1 Cullin Ubiquitin Ligases; SKP Cullin F Box Protein Ligases; Ligases, SKP1-Cullin Ubiquitin; Ligase, Skp1-Cullin-1-F-box Ubiquitin; Ligase, SCF Ubiquitin; Skp1-Cullin-F-Box Proteins; Skp1-Cullin-1-F-box Ubiquitin Ligase; SKP1-Cullin Ubiquitin Ligases; SCF(beta-TrCP) Ubiquitin Ligase; SCF(Fbw7) Ubiquitin Ligase; SCF Ubiquitin Ligase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SKR-1 protein, C elegans  EC 6.3.2.19   *Caenorhabditis elegans Proteins *SKP Cullin F-Box Protein Ligases. Science 2007 Aug 17;317(5840):907-8
SKP1 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *SKP Cullin F-Box Protein Ligases. Genes Cells 2004 May;9(5):367-82
Fbxo32 protein, rat  EC 6.3.2.19   *Muscle Proteins *SKP Cullin F-Box Protein Ligases.
Fbxo32 protein, mouse  EC 6.3.2.19   *Muscle Proteins *SKP Cullin F-Box Protein Ligases.
HRT1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *SKP Cullin F-Box Protein Ligases.
ASK2 protein, Arabidopsis  0   *Arabidopsis Proteins *SKP Cullin F-Box Protein Ligases. Plant Cell 2004 Jan;16(1):5-20
FBXO6 protein, human  EC 6.3.2.19   *SKP Cullin F-Box Protein Ligases. J Biol Chem 2003 Oct 31;278(44):43877-84
Pof10 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *F-Box Proteins *SKP Cullin F-Box Protein Ligases. Biochem Biophys Res Commun 2002 Feb 8;290(5):1399-407
FBXO32 protein, human  EC 6.3.2.19   *Muscle Proteins *SKP Cullin F-Box Protein Ligases. Proc Natl Acad Sci U S A 2001 Dec 4;98(25):14440-5; Science 2001 Nov 23;294(5547):1704-8
SkpA protein, Drosophila  0   *Drosophila Proteins *SKP Cullin F-Box Protein Ligases. Biochem Biophys Res Commun 2001 Aug 17;286(2):357-64
SKP1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *F-Box Proteins *SKP Cullin F-Box Protein Ligases. Yeast 1999 Jun 30;15(9):793-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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