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Fatty Acid Desaturases

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Definition: A family of enzymes that catalyze the stereoselective, regioselective, or chemoselective syn-dehydrogenation reactions. They function by a mechanism that is linked directly to reduction of molecular OXYGEN.     
Examples beta-Carotene 15,15'-Monooxygenase; Linoleoyl-CoA Desaturase; Stearoyl-CoA Desaturase 		Other names Reductases, Enoyl CoA; Desaturases, Fatty Acid; Enoyl CoA Reductases; Acyl CoA Desaturases; Fatty Acid Desaturating Enzymes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
carotene-9',10'-monooxygenase, mouse  EC 1.14.99.-   *Fatty Acid Desaturases. J Nutr. 2010 Dec;140(12):2134-8
carotenoid 9',10'-monooxygenase 2, rat  EC 1.14.99.-   *Fatty Acid Desaturases. J Nutr 2010 Oct;140(10):1808-14
FAD4 protein, Arabidopsis  EC 1.14.19.-   *Arabidopsis Proteins *Fatty Acid Desaturases. Plant J 2009 Dec;60(5):832-9
FADS3 protein, human  EC 1.14.19.3   *Fatty Acid Desaturases. PLoS Genet 2009 Sep;5(9):e1000642
FADS2 protein, human  EC 1.14.19.3   *Fatty Acid Desaturases. J Nutr 2008 Nov;138(11):2222-8
desaturase F, Drosophila melanogaster  EC 1.14.99.-   *Drosophila Proteins *Fatty Acid Desaturases. Insect Biochem Mol Biol 2008 Feb;38(2):244-55
SFD2 protein, Arabidopsis  EC 1.14.99.-   *Arabidopsis Proteins *Fatty Acid Desaturases. Plant J 2008 Apr;54(1):106-17
FAD2 protein, Arabidopsis  EC 1.14.99.-   *Fatty Acid Desaturases. Plant Cell 1994 Jan;6(1):147-58
Tsc13 protein, Arabidopsis  EC 1.14.99.-   *Arabidopsis Proteins *Fatty Acid Desaturases Protein Subunits. J Biol Chem 2007 Jun 29;282(26):19237-46
desatF protein, Drosophila  EC 1.14.99.-   *Drosophila Proteins *Fatty Acid Desaturases. Insect Mol Biol 2006 Aug;15(4):465-73
BCO2 protein, human  EC 1.14.99.-   *Fatty Acid Desaturases. J Histochem Cytochem 2005 Nov;53(11):1403-12
desat2 protein, Bombyx mori  EC 1.14.99.-   *Fatty Acid Desaturases.
desat1 protein, Bombyx mori  EC 1.14.99.-   *Fatty Acid Desaturases.
desat2 protein, Drosophila  EC 1.14.99.-   *Drosophila Proteins *Fatty Acid Desaturases.
palmitoyl-monogalactosyldiacylglycerol delta(7)-desaturase, Arabidopsis  EC 1.14.99.-   *Arabidopsis Proteins *Fatty Acid Desaturases. Plant Physiol 2004 Dec;136(4):4237-45
fat-2 protein, C elegans  0   *Caenorhabditis elegans Proteins *Fatty Acid Desaturases. J Biol Chem. 2004 Sep 17;279(38):39296-302
fad3 protein, Arabidopsis  EC 1.14.99.-   *Arabidopsis Proteins *Fatty Acid Desaturases. Planta. 2001 Oct;213(6):833-40
acyl-CoA delta10-desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Insect Biochem Mol Biol 2002 Sep;32(9):961-6
acyl-CoA delta9-desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Insect Biochem Mol Biol 2002 Sep;32(9):961-8
fat-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Fatty Acid Desaturases. J Neurochem 2002 Sep;82(6):1360-6
delta-4 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. J Biol Chem 2001 Aug 24;276(34):31561-6
stearoyl ACP desaturase, Arabidopsis  EC 1.14.99.-   *Arabidopsis Proteins *Fatty Acid Desaturases. Proc Natl Acad Sci U S A 2001 Jul 31;98(16):9448-53
FADX-2 protein, Calendula officinalis  EC 1.14.99.-   *Plant Proteins *Fatty Acid Desaturases. J Biol Chem 2001 Jan 26;276(4):2637-43
FADX-1 protein, Calendula officinalis  EC 1.14.99.-   *Plant Proteins *Fatty Acid Desaturases. J Biol Chem 2001 Jan 26;276(4):2637-43
desat1 protein, Drosophila  EC 1.14.99.-   *Drosophila Proteins *Fatty Acid Desaturases. Gene 2000 Apr 4;246(1-2):339-45
delta11-myristoyl-coenzyme A desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Biochemistry 1999 Nov 16;38(46):15272-7
SC 26196  0   *Piperazines Fatty Acid Desaturases. Lipids 1999;34 Suppl:S149
delta-8 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Arch Biochem Biophys 1999 May 15;365(2):307-16
acetylenase  EC 1.14.99.-   *Fatty Acid Desaturases Alkynes. Science 1998 May 8;280(5365):915-8
DEGS1 protein, human  EC 1.14.99.-   *Fatty Acid Desaturases. Biochemistry 1997 Jun 10;36(23):6960-7
delta-15 desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Plant Physiol 1995 Jun;108(2):861
Fad7 protein, Arabidopsis  EC 1.14.99.-   *Arabidopsis Proteins *Fatty Acid Desaturases. J Biol Chem 1993 Nov 15;268(32):24099-105
omega-3 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Science 1992 Nov 20;258(5086):1353-5
delta-13 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Arch Insect Biochem Phyisol 1990;14(1):47-56
delta-12 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases Arabidopsis Proteins. Can J Biochem Cell Biol 1983;61(11):1191
delta-22 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases Cytochrome P-450 Enzyme System. Biochem Biophys Res Commun 1983;116(1):162
delta-5 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Int J Biochem 1981;13(7):831
delta-9 fatty acid desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Lipids 1981;16(1):68
phospholipid desaturase  EC 1.-   *Fatty Acid Desaturases. Lipids 14(2):159;1979
palmitoyl-CoA desaturase  EC 1.14.99.-   *Fatty Acid Desaturases. Biochim Biophys Acta 488:442;1977; Biochim Biophys Acta 572(1):178;1979; J Neurochem 32(2):659;1979; Masui 28(9):952;1979
Phosphatidylcholine desaturase  EC 1.3.1.35   *Oxidoreductases Acting on CH-CH Group Donors *Fatty Acid Desaturases. Biochem J 179(3):649;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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