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Cyclotides

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Definition: A continuous circle of peptide bonds, typically of 2-3 dozen AMINO ACIDS, so there is no free N- or C-terminus. They are further characterized by six conserved CYSTEINE residues that form CYSTINE KNOT MOTIFS.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
hedyotide B1  0   *Cyclotides. Biochemistry. 2011 Aug 23;50(33):7275-83
kalata B2  0   *Cyclotides. Environ Toxicol Chem. 2011 Aug;30(8):1785-92
kalata B5, Oldenlandia affinis  0   *Cyclotides Plant Proteins. Biopolymers. 2010;94(5):647-58
psyle E  0   *Cyclotides. J Nat Prod. 2010 Jul 23;73(7):1207-13
psyle A  0   *Cyclotides. J Nat Prod. 2010 Jul 23;73(7):1207-13
psyle C  0   *Cyclotides. J Nat Prod. 2010 Jul 23;73(7):1207-13
kalata B7, Oldenlandia affinis  0   *Cyclotides. J Inorg Biochem 2008 May-Jun;102(5-6):1246-56
cycloviolacin O24  0   *Cyclotides. Biopolymers 2008;90(1):51-60
cycloviolacin O14  0   *Cyclotides. Biopolymers 2008;90(1):51-60
cycloviolacin O13  0   *Cyclotides. Biopolymers 2008;90(1):51-60
cycloviolacin Y4  0   *Cyclotides. J Nat Prod 2008 Jan;71(1):47-52
cycloviolacin Y5  0   *Cyclotides. J Nat Prod 2008 Jan;71(1):47-52
violacin A  0   *Cyclotides. J Mol Biol. 2006 Apr 14;357(5):1522-35
cycloviolacin H4  0   *Cyclotides. J Nat Prod 2006 Jan;69(1):23-8
VHL-1 protein, Viola hederaceae  0   *Cyclotides. J Biol Chem 2005 Jun 10;280(23):22395-405
kalata B6  0   *Cyclotides. Anal Biochem 2005 Feb 1;337(1):149-53
cycloviolacin O2  0   *Cyclotides. Mol Cancer Ther 2002 Apr;1(6):365-9
varv A  0   *Cyclotides. Mol Cancer Ther 2002 Apr;1(6):365-9
varv F  0   *Cyclotides. Mol Cancer Ther 2002 Apr;1(6):365-9
palicourein  0   *Cyclotides. J Nat Prod 2001 Feb;64(2):249-50
MCoTI-III protein, Momordica cochinchinensis  0   *Plant Proteins *Cyclotides. Biochemistry 2000 May 16;39(19):5722-30
trypsin inhibitor MCoTI-II  0   *Cyclotides. Biochemistry 2000 May 16;39(19):5722-30
MCoTI-I protein, Momordica cochinchinensis  0   *Plant Proteins *Cyclotides. Biochemistry 2000 May 16;39(19):5722-30
circulin B  20905-50-4   *Cyclotides. Biochem Biochem Res Commun 1996 Nov 12;228(2):632-8
circulin A  5854-98-8   *Cyclotides. Biochem Biochem Res Commun 1996 Nov 12;228(2):632-8
cyclopsychotride A  0   *Cyclotides. J Nat Prod 1994 Dec;57(12):1619-25
kalata B1  0   *Cyclotides Rubiaceae Cystine Knot Motifs. Protein Sci 1994 Oct;3(10):1833-9
PMP-C peptide, insect  140880-00-8   *Insect Proteins *Cyclotides Nerve Tissue Proteins Cystine Knot Motifs. Eur J Biochem 1992 Feb 15;204(1):147-53
PMP-D2 peptide, insect  140879-98-7   *Cyclotides *Insect Proteins Nerve Tissue Proteins Cystine Knot Motifs. Eur J Biochem 1992 feb 15;204(1):147-53
circulin  9008-54-2 Circulin  *Cyclotides. J Chromatogr 112:663;1975

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