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Polyketide Synthases

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Definition: Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.      Other names Type II Polyketide Beta Ketoacyl Synthase; Synthases, Polyketide; Synthase, WhiE Polyketide; Synthase, Urdamycin Polyketide; Synthase, Sterigmatocystin Polyketide; Synthase, Rifamycin Polyketide; Synthase, Niddamycin Polyketide; Synthase, Griseusin Polyketide; Synthase, Erythromycin Polyketide; Synthase, Epothilone Polyketide; Synthase, 6-Deoxyerythronolide-B; Synthase WA, Polyketide; Synthase L1, Polyketide; Protein, WdPKS1; Polyketide Synthase, WhiE; Polyketide Synthase, Urdamycin; Polyketide Synthase, Sterigmatocystin; Polyketide Synthase, Rifamycin; Polyketide Synthase, Niddamycin; Polyketide Synthase, Griseusin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LAP6 protein, Arabidopsis  0   *Arabidopsis Proteins *Polyketide Synthases. Plant Physiol 2010 Jul;153(3):937-55
LAP5 protein, Arabidopsis  0   *Arabidopsis Proteins *Polyketide Synthases. Plant Physiol 2010 Jul;153(3):937-55
lovastatin nonaketide synthase, Aspergillus terreus  0   *Polyketide Synthases. Science. 2009 Oct 23;326(5952):589-92
1,3,6,8-tetrahydroxynaphthalene synthase, Streptomyces coelicolor  0   *Polyketide Synthases. J Nat Prod 2002 Dec;65(12):1956-62
polyketide beta-ketoacylsynthase  EC 2.3.1.-   *Polyketide Synthases Macrolides. Gene 1994 May 3;142(1):31-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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