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Kynurenine 3-Monooxygenase

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Definition: An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3-hydroxykynurenine. It was formerly characterized as EC 1.14.1.2 and EC 1.99.1.5.      Other names L Kynurenine 3 Hydroxylase; Kynurenine 3 Monooxygenase; Kynurenine 3 Hydroxylase; Hydroxylase, Kynurenine; 3-Monooxygenase, Kynurenine; 3-Hydroxylase, Kynurenine; L-Kynurenine-3-Hydroxylase; Kynurenine Hydroxylase; Kynurenine 3-Hydroxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(+-)-dichlorobenzoylcyclopropane carboxylic acid  0   *Cyclopropanes Kynurenine 3-Monooxygenase/antagonists & inhibitors. J Neurosci Res. 2007 Mar;85(4):845-54

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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