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Core Binding Factor alpha Subunits

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Definition: A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.     
Examples Core Binding Factor Alpha 1 Subunit; Core Binding Factor Alpha 2 Subunit; Core Binding Factor Alpha 3 Subunit 		Other names Transcription Factors, PEBP2A; Runt Domain Factor; Polyomavirus Enhancer Binding Protein 2, Alpha Sub; Polyomavirus Enhancer A Binding Protein 2; PEBP2A Transcription Factors; Acute Myeloid Leukemia Proteins; Runx Proteins; Core Binding Factor alpha Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
core binding factor alpha  0   *Core Binding Factor alpha Subunits. FEBS Lett 2000 Mar 24;470(2):167-72

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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