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POU Domain Factors

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Definition: A family of transcription factors characterized by the presence of a bipartite DNA-binding domain known as the POU domain. The POU domain contains two subdomains, a POU-specific domain and a POU-homeodomain. The POU domain was originally identified as a region of approximately 150 amino acids shared between the Pit-1, Oct-1, Oct-2, and Unc-86 transcription factors.     
Examples Octamer Transcription Factors; Transcription Factor Brn-3; Transcription Factor Pit-1 		Other names POU, Transcription Factor; Transcription Factor POU; Pit-Oct-Unc Proteins; POU Proteins; Pit Oct Unc Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
OCT-25 protein, Xenopus  0   *Xenopus Proteins *POU Domain Factors. Mech Dev 2007 Nov-Dec;124(11-12):840-55
pou12 protein, zebrafish  0   *Nerve Tissue Proteins *Zebrafish Proteins *POU Domain Factors.
Pou-2 protein, Xenopus  0   *Xenopus Proteins *POU Domain Factors.
Pou6f1 protein, mouse  0   *POU Domain Factors.
sperm 1 protein, human  0   *POU Domain Factors Spermatogenesis.
Sprm1 protein, mouse  0   *POU Domain Factors Spermatogenesis.
Pou3f4 protein, rat  0   *Nerve Tissue Proteins *POU Domain Factors.
nubbin protein, Drosophila  0   *Homeodomain Proteins *Drosophila Proteins *POU Domain Factors. Nature 1997 Feb 13;385(6617):627-30
pou50 protein, zebrafish  0   *Nerve Tissue Proteins *Zebrafish Proteins *POU Domain Factors. Development 1996 Jun;122(6):1769-80
POU6F2 protein, human  0   *POU Domain Factors Eye Proteins Nerve Tissue Proteins. J Neurosci 1996 Apr 1;16(7):2261-74
POU3F4 protein, human  0   *POU Domain Factors. Science 1995 Feb 3;267(5198):685-8
vvl protein, Drosophila  0   *Drosophila Proteins *POU Domain Factors. Genes Dev 1995 Jan 1;9(1):123-37
Pou3f-rs1 protein, mouse  0   *POU Domain Factors. Biochem Biophys Res Commun 1994 Apr 15;200(1):156-62
Pou4f-rs1 protein, mouse  0   *POU Domain Factors. Biochem Biophys Res Commun 1994 Apr 15;200(1):156-62
Pit1-rs1 protein, mouse  0   *POU Domain Factors. Biochem Biophys Res Commun 1994 Apr 15;200(1):156-62
POU-M1 protein, Bombyx mori  0   *Insect Proteins *POU Domain Factors. J Biol Chem 1994 Jan 28;269(4):3733-42
transcription factor Brn-2  0   *Homeodomain Proteins *POU Domain Factors. Neuron 1993 Dec;11(6):1197-1206
sperm 1 protein, rat  0   *POU Domain Factors Spermatogenesis. Proc Natl Acad Sci U S A 1993 Dec 1;90(23):11084-8
Pou6f1 protein, rat  0   *POU Domain Factors. J Biol Chem 1993 Apr 5;268(10):7449-57; J Biol Chem 1993 Nov 5;268(31):23390-8
POU6F1 protein, human  0   *POU Domain Factors. Mol Cell Biol 1993 Sep;13(9):5450-60
unc-86 protein, C elegans  122158-15-0   *Homeodomain Proteins *Caenorhabditis elegans Proteins *POU Domain Factors. Curr Opin Genet Dev 1993 Apr;3(2):275-7
POUC protein, zebrafish  0   *Zebrafish Proteins *POU Domain Factors. Nucleic Acids Res 1993 Feb 11;21(3):475-83
POU1 protein, zebrafish  148970-54-1   *Nerve Tissue Proteins *Zebrafish Proteins *POU Domain Factors. Biochem Biophys Res Commun 1992 Sep 30;197(3):1446-53
Pou3f4 protein, mouse  147258-09-1   *Nerve Tissue Proteins *POU Domain Factors. Proc Natl Acad Sci U S A 1992 Apr 15;89(8):3280-4
Pou3f2 protein, mouse  147258-11-5   *Nerve Tissue Proteins *POU Domain Factors. Proc Natl Acad Sci U S A 1992 Apr 15;89(8):3280-4
Pou3f3 protein, mouse  147258-10-4   *Nerve Tissue Proteins *POU Domain Factors. Proc Natl Acad Sci U S A 1992 Apr 15;89(8):3280-4
pdm2 protein, Drosophila  0   *Homeodomain Proteins *Drosophila Proteins *POU Domain Factors. Mech Dev 1991 Dec;36(1-2):87-102
acj6 protein, Drosophila  138157-26-3   *Nerve Tissue Proteins *Drosophila Proteins *POU Domain Factors. Nature 1991;350(6319):577; Neuron 1999 Feb;22(2):339-47

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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