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Serine C-Palmitoyltransferase

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Definition: A key enzyme in SPHINGOLIPIDS biosynthesis, this enzyme catalyzes the pyridoxal-5'-phosphate-dependent condensation of L-SERINE and PALMITOYL COENZYME A to 3-dehydro-D-sphinganine. The enzyme consists of two different subunits.      Other names Transferase 2, Serine-Palmitoyl-CoA; Serine Palmitoyl CoA Transferase 2; Serine C Palmitoyltransferase; Palmitoyltransferase, Serine; Palmitoyltransferase 2, Serine; Palmitoyltransferase 1, Serine; C-Palmitoyltransferase, Serine; Serine-Palmitoyl-CoA Transferase 2; Serine Palmitoyltransferase, Long Chain Base Subun; Serine Palmitoyltransferase, Long Chain Base Subun; Serine Palmitoyltransferase 2; Serine Palmitoyltransferase 1; Serine Palmitoyltransferase; Palmitoyl-Coenzyme A-L-Serine C-Palmitoyltransfera; Palmitoyl-CoA-L-Serine C-Palmitoyltransferase (Dec; Long Chain Base Biosynthesis Protein 2; Long Chain Base Biosynthesis Protein 1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ssSPTa  EC 2.3.1.50   *Serine C-Palmitoyltransferase Protein Isoforms. Proc Natl Acad Sci U S A 2009 May 19;106(20):8186-91
Lcb2 protein, Arabidopsis  EC 2.3.1.50   *Arabidopsis Proteins *Serine C-Palmitoyltransferase. Plant Physiol 2008 Mar;146(3):1322-32
SPTLC3 protein, human  EC 2.3.1.50   *Serine C-Palmitoyltransferase Protein Subunits. J Biol Chem 2006 Dec 8;281(49):37275-81
LCB1 protein, Arabidopsis  EC 2.3.1.50   *Arabidopsis Proteins *Serine C-Palmitoyltransferase Protein Subunits. Plant Cell 2006 Dec;18(12):3576-93
SPTSSB protein, human  EC 2.3.1.50   *Membrane Proteins *Serine C-Palmitoyltransferase. Gene 2005 Mar 28;348:55-63
Sptlc2 protein, mouse  EC 2.3.1.50   *Serine C-Palmitoyltransferase.
SPTLC2 protein, human  EC 2.3.1.50   *Serine C-Palmitoyltransferase.
Sptlc1 protein, mouse  EC 2.3.1.50   *Serine C-Palmitoyltransferase.
LCB2 protein, S cerevisiae  EC 2.3.1.50   *Saccharomyces cerevisiae Proteins *Serine C-Palmitoyltransferase.
LCB1 protein, S cerevisiae  EC 2.3.1.50   *Saccharomyces cerevisiae Proteins *Serine C-Palmitoyltransferase.
SPTLC1 protein, human  EC 2.3.1.50   *Serine C-Palmitoyltransferase. Eur J Biochem 1997 Oct 1;249(1):239-47

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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