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Inhibitor of Differentiation Proteins

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Definition: Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.     
Examples Inhibitor of Differentiation Protein 1; Inhibitor of Differentiation Protein 2 		Other names Differentiation Proteins Inhibitor; ID DNA Binding Protein Inhibitor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Id3 protein, Xenopus  0   *Xenopus Proteins *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs. Development 2005 Apr;132(8):1831-41
Id3 protein, rat  0   *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs. Circ Res 2004 Sep 17;95(6):557-9
ID4 protein, human  0   *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs.
Id4 protein, Xenopus  0   *Xenopus Proteins *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs.
Idb4 protein, rat  0   *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs.
Idb4 protein, mouse  0   *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs. Nucleic Acids Res 1994 Mar 11;22(5):749-55
ID3 protein, human  147785-34-0   *Neoplasm Proteins *Inhibitor of Differentiation Proteins Neuroblastoma Helix-Loop-Helix Motifs. EMBO J 1992 Jul;11(7):2563-71
Idb3 protein, mouse  135845-89-5   *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs. Proc Natl Acad Sci USA 1991;88(5):1815

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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