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RecQ Helicases

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Definition: A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.     
See Also Bloom Syndrome; Rothmund-Thomson Syndrome; Werner Syndrome 		Other names Helicases, RecQ; Helicase, RecQL4; Helicase, RecQL3; Helicase, RecQL2; Helicase, RecQL; Helicase, RecQ5L; Helicase, RecQ5; Helicase, RecQ3; Helicase, RecQ2; Helicase, RTS; Helicase, RECQL1; DNA Helicase, RecQ like type 2; DNA Dependent ATPase Q1; ATP Dependent DNA Helicase Q5; ATP Dependent DNA Helicase Q4; ATP Dependent DNA Helicase Q1; RecQL4 Helicase; RecQL3 Helicase; RecQL2 Helicase; RecQL Helicase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Hrq1 protein, S pombe  EC 3.6.1.-   *Schizosaccharomyces pombe Proteins *RecQ Helicases. Mol Cell Biol. 2012 Jan;32(2):276-87.
RecQ5 protein, Drosophila  EC 3.6.1.3   *Drosophila Proteins *RecQ Helicases. DNA Repair (Amst) 2009 Feb 1;8(2):232-41
RECQL5 protein, human  0   *RecQ Helicases.
RECQL4 protein, human  EC 3.6.1.-   *RecQ Helicases.
RECQL protein, human  EC 3.6.1.-   *RecQ Helicases.
RecQ protein, E coli  EC 3.6.1.-   *RecQ Helicases.
Recql5 protein, mouse  EC 5.99.-   *RecQ Helicases. Gene 2001 Dec 12;280(1-2):59-66
Wrn protein, mouse  EC 5.99.-   *RecQ Helicases Werner Syndrome. Cancer Genet Cytogenet 2005 Jan 15;156(2):134-43
RecQsim protein, Arabidopsis  EC 5.99.-   *Arabidopsis Proteins *RecQ Helicases. Plant Mol Biol 2003 May;52(2):273-84
WRN protein, human  EC 3.6.1.-   *Exodeoxyribonucleases *RecQ Helicases Werner Syndrome. Science 1996 Apr 12;272(5259):258-62
Bloom syndrome protein  EC 3.6.1.-   *RecQ Helicases Bloom Syndrome. Nature 1995 Dec 7;378(6557):557-8
SGS1 protein, S cerevisiae  EC 3.6.1.-   *Saccharomyces cerevisiae Proteins *RecQ Helicases. Mol Cell Biol 1994 Dec;14(12):8391-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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