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Presenilin-2

More information in Books or onNLM PubMed
Definition: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.      Other names Presenilin 2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
presenilin 2 protein, zebrafish  0   *Zebrafish Proteins *Presenilin-2. Exp Cell Res. 2009 Oct 1;315(16):2791-801
PSEN2 protein, human  0   *Presenilin-2.
Psen2 protein, mouse  0   *Presenilin-2 Apoptosis. Science 1995 Aug 18;269(5226):973-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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