Perforin (definition)

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Perforin

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Definition: A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.

Pharmacological Action Cytotoxins

Other names Pore-Forming Protein, Lymphocyte; Lymphocyte Pore Forming Protein; Perforin 1; Lymphocyte Pore-Forming Protein; Cytolysin

Substance	CAS Registry & name	Categories	Source	Drugs*
perforin-like protein 1, Toxoplasma gondii	0	Protozoan Proteins Perforin.	Science 2009 Jan 23;323(5913):530-3

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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