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Withanolides

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Definition: Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
dioscorolide B  0   *Withanolides Antineoplastic Agents, Phytogenic. J Agric Food Chem. 2011 Jul 13;59(13):6980-4
dioscorolide A  0   *Withanolides Antineoplastic Agents, Phytogenic. J Agric Food Chem. 2011 Jul 13;59(13):6980-4
dinoxin B  0   *Glucosides *Withanolides. J Nat Prod. 2011 Feb 25;74(2):267-71
mandragorolide B  0   *Withanolides. Fitoterapia. 2010 Oct;81(7):864-8
mandragorolide A  0   *Withanolides. Fitoterapia. 2010 Oct;81(7):864-8
4-hydroxywithanolide E  0   *Withanolides. BMC Cancer 2010;10:46
(20R,22R)-5beta,6beta-epoxy-4beta,12beta,20-trihydroxy-1-oxowith-2-en-24-enolide  0   *Withanolides. J Nat Prod. 2010 Jul 23;73(7):1313-7
(20R,22R)-16beta-acetoxy-3beta,4beta;5beta,6beta-diepoxy-12beta,20-dihydroxy-1-oxowith-24-enolide  0   *Withanolides. J Nat Prod. 2010 Jul 23;73(7):1313-7
1,10-seco withaperuvin C  0   *Withanolides. J Asian Nat Prod Res. 2010 Jul;12(7):618-22
virginol B  0   *Withanolides. Steroids. 2010 Apr;75(4-5):346-9
virginol A  0   *Withanolides. Steroids. 2010 Apr;75(4-5):346-9
virginol C  0   *Withanolides. Steroids. 2010 Apr;75(4-5):346-9
12-acetoxy-4-deoxy-5,6-deoxy-delta5-withanolide D  0   *Withanolides. Fitoterapia 2009 Sep;80(6):364-8
nicandrenone  0   *Withanolides. Nat Prod Commun 2009 Jun;4(6):783-8
coagulanolide  0   *Withanolides. Bioorg Med Chem Lett 2008 Dec 15;18(24):6534-7
withanolide Z  0   *Withanolides. Planta Med 2008 Nov;74(14):1745-8
withangulatin I  0   *Withanolides. Chem Pharm Bull (Tokyo) 2008 Feb;56(2):234-6
jaborosalactone 44  0   *Withanolides. J Nat Prod 2007 Sep;70(9):1513-5
jaborosalactone 43  0   *Withanolides. J Nat Prod 2007 Sep;70(9):1513-5
3-rhamnopyranosyl(1-4)-glucopyranosyl-12-diacetoxy-20-hydroxywitha-5,24-dienolide  0   *Withanolides Withania. J Nat Prod 2001 Jun;64(6):720-5
withanolide D  30655-48-2 (4 beta,5 beta,6 beta,22R)-5,6-epoxy-4,20,22-trihydroxy-1-oxoergosta- 2,24-dien-26-oic acid, delta-lactone  *Withanolides. Arch Pharm 310(1):35;1977; Biochem Pharmacol 24(8):919;1975; Biomedicine 28(1):18;1978; Chem Pharm Bull (Tokyo) 24(6):1403;1976; J Chem Soc Perkin I 7:795;1977
withaferin A  5119-48-2 (4 beta,5 beta,6 beta,22R)-5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta- 2,24-dien-26-oic acid, delta-lactone  *Withanolides. Biochem Pharmacol 24(8):919;1975; Biomedicine 28(1):18;1978; Cancer Lett 2(2):63;1976; Cancer Lett 2(2):71;1976; J Chromatogr 137(2):465;1977; Steroids 31(5):671;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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