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Phospholipases A2, Secretory

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Definition: A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing multiple disulfide-bonds and access their substrate via an interfacial binding site that interacts with phospholipid membranes. In addition specific PHOSPHOLIPASE A2 RECEPTORS can bind to and internalize the enzymes.  general; prefer specifics   
Examples Group I Phospholipases A2; Group II Phospholipases A2; Group III Phospholipases A2; Group V Phospholipases A2; Group X Phospholipases A2 		Other names Secretory Phospholipases A2; Phospholipases, SPLA2; Phospholipase A2, Secretory; sPLA2s; Secretory Phospholipase A2; Secreted Phospholipases A2; SPLA2 Phospholipases; Phospholipases A2, Secreted; sPLA(2)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(3-aminooxalyl-1-benzyl-2-ethyl-6-methyl-1H-indol- 4-yloxy)-acetic acid methyl ester  0   *Indoleacetic Acids Phospholipases A2, Secretory/antagonists & inhibitors. Exp Lung Res 2010 May;36(4):191-200
secreted phospholipase A2 group XII protein, Xenopus  EC 3.1.1.4   *Xenopus Proteins *Phospholipases A2, Secretory. Mol Cell Biol 2005 May;25(9):3608-19
conodipine M  EC 3.1.1.4   *Phospholipases A2, Secretory Mollusk Venoms. J Biol Chem 1995 Feb 24;270(8):3518-26

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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