Definition: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
Other names Protein Tyrosine Phosphatase, Non Receptor Type 12; Phosphatase, PEST-Enriched; PTPase, PEP; PEST Enriched Phosphatase; PTP-PEST; PEST-Enriched Phosphatase; PEP Protein Tyrosine Phosphatase; PEP PTPase
