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Bryostatins

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Definition: A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
20-deoxybryostatin  0   *Bryostatins. Chem Commun (Camb). 2011 Jul 7;47(25):7200-2
Merle 23  0   *Bryostatins. Biochem Pharmacol. 2011 Jun 1;81(11):1296-308
bryostatin 20  0   *Bryostatins. Oecologia. 2004 Mar;139(1):131-9
bryostatin 7  0   *Bryostatins. Org Lett. 2003 Feb 20;5(4):503-5
bryostatin 18  0   *Bryostatins. J Nat Prod 1996 Mar;59(3):286-9
bryostatin 17  0   *Bryostatins. J Nat Prod 1996 Mar;59(3):286-9
bryostatin 16  0   *Bryostatins. J Nat Prod 1996 Mar;59(3):286-9
bryostatin 10  102580-65-4   *Bryostatins. J Nat Prod 1995 Dec;58(12):1868-75
bryostatin 5  97850-04-9 Bryostatin 1, 20-O-acetyl-7-O-deacetyl-20-O-de(1-oxo-2,4-octadienyl)-7-O-(3-methyl-1-oxobutyl)  *Bryostatins Enzyme Activation. J Cell Biochem 1992 Aug;49(4):417-24
bryostatin 8  102580-64-3   *Bryostatins. J Biol Chem 1991;266(17):11205
bryostatin 3  87370-86-3   *Bryostatins. J Biol Chem 1991;266(17):11205
bryostatin 4  91523-82-9   *Bryostatins Colony-Stimulating Factors Growth Substances. Haematologica (Pavia) 1988;73(5):387
bryostatin 2  87745-28-6   *Bryostatins. J Immunol 1988;140(2):433
bryostatin 1  83314-01-6   *Bryostatins Enzyme Activation Mitogens.
Pharma Action Adjuvants, Immunologic ; Antineoplastic Agents 		Biochem Biophys Res Commun 1985;131(3):1109

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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