Ribosome Inactivating Proteins (definition)

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ψ ψ	Ribosome Inactivating Proteins

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Definition: N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.

Pharmacological Action Protein Synthesis Inhibitors
Examples Ribosome Inactivating Proteins, Type 1; Ribosome Inactivating Proteins, Type 2

Other names rRNA N Glycosylases; RNA N Glycosidase; Proteins, Ribosome Inactivating; N-Glycosylases, rRNA; N-Glycosidase, RNA; Inactivating Proteins, Ribosome; Glycosylase, RNA; Glycosidase, Polynucleotide Adenosine; Adenosine Glycosidase, Polynucleotide; rRNA N-Glycosylases; RNA Glycosylase; RIP (Ribosome Inactivating Proteins); Polynucleotide Adenosine Glycosidase; RNA N-Glycosidase

Substance	CAS Registry & name	Categories	Source
lychnin	0	*Ribosome Inactivating Proteins.	Biol Chem 2006 Sep;387(9):1261-6
ME1 N-glycosidase	EC 3.2.2.-	*Ribosome Inactivating Proteins.	J Biol Chem 2004 Aug 13;279(33):34165-74
VAA-I protein, Viscum album	0	Toxins, Biological Ribosome Inactivating Proteins.
mistletoe lectin III	0	Toxins, Biological Ribosome Inactivating Proteins.
mistletoe lectin II	0	Toxins, Biological Ribosome Inactivating Proteins.
viscotoxin	76822-96-3	*Plant Proteins Ribosome Inactivating Proteins Thionins.	Hoppe Seylers Z Physiol Chem. 1980 Oct;361(10):1525-33; Sven Farm Tidskr. 1958 Mar 20;62(8):169-89
Velutin protein, Flammulina velutipes	0	Fungal Proteins Ribosome Inactivating Proteins.	Life Sci 2001 Mar 23;68(18):2151-8
pokeweed lectin D	181055-22-1	Pokeweed Mitogens Ribosome Inactivating Proteins.	Biosci Biotechnol Biochem 1996 Aug;60(8):1380-2
pokeweed lectin C	0	Pokeweed Mitogens Ribosome Inactivating Proteins.	Biosci Biotech Biochem 1995 Jul;59(7):1384-5
snowdrop lectin	0	Plant Lectins Mannose-Binding Lectins Ribosome Inactivating Proteins.	Methods Enzymol 1989;179:327
cinnamomin, Phytophthora cinnamomi	115742-69-3	*Algal Proteins Ribosome Inactivating Proteins.	Eur J Biochem. 2001 Nov;268(22):5723-33; FEBS Lett 1989;257(2):302
amaranthin protein, Amaranthus	0	Plant Lectins Ribosome Inactivating Proteins Amaranthus.	J Biol Chem 1989;264(27):16123
Sambucus nigra lectins	0	Plant Lectins Ribosome Inactivating Proteins Glycoproteins.	Exp Hematol 1986;14(10):946
MMC protein, Momordica charantia	88026-31-7	Ribosome Inactivating Proteins. Pharma Action* Abortifacient Agents, Nonsteroidal ; Antineoplastic Agents, Phytogenic	J Reprod Fertil 1983;69(2):597

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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