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SOX Transcription Factors

More information in Books or onNLM PubMed
Definition: A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are organized in several subgroups according to structural identities found within the proteins.  do not confuse entry term SRY (SEX DETERMINING REGION Y)-BOX PROTEINS with SRY SEX-DETERMINING REGION PROTEIN see SEX-DETERMINING REGION Y PROTEIN   
Examples Sex-Determining Region Y Protein; SOXB1 Transcription Factors; SOXB2 Transcription Factors; SOXC Transcription Factors; SOXD Transcription Factors; SOXE Transcription Factors; SOXF Transcription Factors 		Other names Transcription Factors, SOX; SRY (Sex Determining Region Y)-Box Proteins; SOX Transcription Factor Family; SOX Family of Transcription Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Sox2 protein, zebrafish  0   *Zebrafish Proteins *SOX Transcription Factors. RNA 2009 Nov;15(11):2013-27
Sox21 protein, Xenopus  0   *Xenopus Proteins *SOX Transcription Factors. Int J Dev Biol 2008;52(7):999-1004
Sox14 protein, Xenopus  0   *Xenopus Proteins *SOX Transcription Factors. Int J Dev Biol 2008;52(7):999-1004
sox11b protein, zebrafish  0   *Zebrafish Proteins *SOX Transcription Factors.
SOX33 protein, Xenopus  0   *Xenopus Proteins *SOX Transcription Factors. Biochim Biophys Acta 2003 Jul 28;1628(2);140-5
sox32 protein, zebrafish  0   *Zebrafish Proteins *SOX Transcription Factors. Genes Dev 2001 Jun 15;15(12):1487-92; Mech Dev 2001 Sep;107(1-2):25-38
sox19b protein, zebrafish  0   *Zebrafish Proteins *SOX Transcription Factors. Mech Dev 2001 Jan;100(1):71-3
SoxNeuro protein, Drosophila  0   *Drosophila Proteins *SOX Transcription Factors. Mech Dev 2000 May;93(1-2):215-9
Dichaete protein, Drosophila  0   *Drosophila Proteins *SOX Transcription Factors. Development 1996 Nov;122(11):3669-76
SOX15 protein, human  0   *SOX Transcription Factors. Cytogenet Cell Genet 1996;72(2-3):246-9
Sox19 protein, zebrafish  0   *Zebrafish Proteins *SOX Transcription Factors. Gene 1995 Feb 14;153(2):275-6
Sox15 protein, mouse  0   *SOX Transcription Factors. Nucleic Acids Res 1993 Apr 11;21(7):1669

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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