Definition: A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
Other names Unfolded Protein Responses; Responses, Unfolded Protein; Response, Unfolded Protein; Protein Responses, Unfolded; Protein Response, Unfolded
