Axin Signaling Complex (definition)

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ψ ψ	Axin Signaling Complex

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Definition: A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

Examples Adenomatous Polyposis Coli Protein; Axin Protein; Casein Kinase I; Glycogen Synthase Kinase 3

Other names beta Catenin Destruction Complex; Signaling Complex, Axin; Destruction Complex, beta-Catenin; beta-Catenin Destruction Complex; Axin Signaling Complex Proteins

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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