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Casein Kinase I

More information in Books or onNLM PubMed
Definition: A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION.     
Examples Casein Kinase Ialpha; Casein Kinase Idelta; Casein Kinase Iepsilon 		Other names Kinase I, Casein; Kinase 1, Casein; tau Casein Kinase I; Protein Kinase CKI; Protein Kinase CK1; Kappa Casein Kinase; Casein Kinase Itau; Casein Kinase Ikappa; Casein Kinase Igamma; Casein Kinase Ibeta; Casein Kinase 1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(3-chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo(3,4-d)pyrimidin-4-ylamine  0   *Pyrazoles *Pyrimidines Casein Kinase I/antagonists & inhibitors. J Pharmacol Exp Ther 2009 Aug;330(2):430-9
4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide  0   *Benzamides *Imidazoles Casein Kinase I/antagonists & inhibitors. EMBO Rep 2004 Jan;5(1):60-5
YCK3 protein, S cerevisiae  EC 2.7.1.37   *Saccharomyces cerevisiae Proteins *Casein Kinase I.
YCK2 protein, S cerevisiae  EC 2.7.1.37   *Saccharomyces cerevisiae Proteins *Casein Kinase I.
YCK1 protein, S cerevisiae  EC 2.7.1.37   *Saccharomyces cerevisiae Proteins *Casein Kinase I.
gilgamesh protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *Casein Kinase I.
HRR25 protein, S cerevisiae  EC 2.7.1.37   *Saccharomyces cerevisiae Proteins *Casein Kinase I. Science 1991;253(5023):1031

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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