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Antigens, CD274

More information in Books or onNLM PubMed
Definition: An inhibitory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN. CD274 antigen provides negative signals that control and inhibit T-cell responses and is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.      Other names PD L1 Costimulatory Protein; Costimulatory Protein, PD-L1; CD274 Antigens; B7 H1 Immune Costimulatory Protein; B7 H1 Antigen; Antigen, B7-H1; Programmed Cell Death 1 Ligand 1; Antigen, CD274; PD-L1 Costimulatory Protein; CD274 Antigen; B7H1 Immune Costimulatory Protein; B7-H1 Immune Costimulatory Protein; B7-H1 Antigen; Programmed Cell Death 1 Ligand 1 Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Cd274 protein, mouse  0   *Antigens, CD274.
CD274 protein, human  0   *Antigens, CD274. Blood 2001 Mar 15;97(6):1809-16; Nat Immunol 2001 Mar;2(3):261-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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